Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor

Currently, there is no available therapy to eradicate hepatitis B virus (HBV) in chronically infected individuals. This is due to the difficulty in eliminating viral covalently closed circular (ccc) DNA, which is central to the gene expression and replication of HBV. We developed an assay system for...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Takeuchi, Fumihiko, Ikeda, Sotaro, Tsukamoto, Yuta, Iwasawa, Yoshikazu, Qihao, Chen, Otakaki, Yukie, Ryota, Ouda, Yao, Wan-Ling, Narita, Ryo, Makoto, Hijikata, Watashi, Koichi, Wakita, Takaji, Takeuchi, Koh, Chayama, Kazuaki, Kogure, Amane, Kato, Hiroki, Fujita, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6380541/
https://ncbi.nlm.nih.gov/pubmed/30779774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0212233
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