Longitudinal liquid biopsy and mathematical modelling of clonal evolution forecast waiting time to treatment failure in the PROSPECT-C phase II colorectal cancer clinical trial

Sequential profiling of plasma cell-free (cf)DNA holds immense promise for early detection of patient relapse. However, how to exploit the predictive power of cfDNA as a liquid biopsy in the clinic remains unclear. RAS pathway aberrations can be tracked in cfDNA to monitor resistance to anti-epiderm...

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Publicat a:Cancer Discov
Autors principals: Khan, Khurum H, Cunningham, David, Werner, Benjamin, Vlachogiannis, Georgios, Spiteri, Inmaculada, Heide, Timon, Mateos, Javier Fernandez, Vatsiou, Alexandra, Lampis, Andrea, Damavandi, Mahnaz Darvish, Lote, Hazel, Huntingford, Ian S., Hedayat, Somaieh, Chau, Ian, Tunariu, Nina, Mentrasti, Giulia, Trevisani, Francesco, Rao, Sheela, Anandappa, Gayathri, Watkins, David, Starling, Naureen, Thomas, Janet, Peckitt, Clare, Khan, Nasir, Rugge, Massimo, Begum, Ruwaida, Hezelova, Blanka, Bryant, Annette, Jones, Thomas, Proszek, Paula, Fassan, Matteo, Hahne, Jens C, Hubank, Michael, Braconi, Chiara, Sottoriva, Andrea, Valeri, Nicola
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6380469/
https://ncbi.nlm.nih.gov/pubmed/30166348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-0891
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