Single cell-produced and in vitro-assembled anti-FcRH5/CD3 T-cell dependent bispecific antibodies have similar in vitro and in vivo properties

Bispecific antibody production using single host cells has been a new advancement in the antibody engineering field. We previously showed comparable in vitro biological activity and in vivo mouse pharmacokinetics (PK) for two novel single cell variants (v10 and v11) and one traditional dual cell in...

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Veröffentlicht in:MAbs
Hauptverfasser: Ovacik, Ayse Meric, Li, Ji, Lemper, Marie, Danilenko, Dimitry, Stagg, Nicola, Mathieu, Mary, Ellerman, Diego, Gupta, Vinita, Kalia, Navdeep, Nguy, Trung, Plaks, Vicki, David Johnson, Clarissa, Wang, Weiru, Brumm, Jochen, Fine, Bernard, Junttila, Teemu, Lin, Kedan, Carter, Paul J., Prabhu, Saileta, Spiess, Christoph, Kamath, Amrita V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2018
Schlagworte:
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6380433/
https://ncbi.nlm.nih.gov/pubmed/30550367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1551676
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