Allele-specific genome editing using CRISPR–Cas9 is associated with loss of heterozygosity in diploid yeast

Targeted DNA double-strand breaks (DSBs) with CRISPR–Cas9 have revolutionized genetic modification by enabling efficient genome editing in a broad range of eukaryotic systems. Accurate gene editing is possible with near-perfect efficiency in haploid or (predominantly) homozygous genomes. However, ge...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autores principales: Gorter de Vries, Arthur R, Couwenberg, Lucas G F, van den Broek, Marcel, de la Torre Cortés, Pilar, ter Horst, Jolanda, Pronk, Jack T, Daran, Jean-Marc G
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2019
Materias:
Molecular Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379674/
https://ncbi.nlm.nih.gov/pubmed/30517747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1216
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