MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers. It thrives in a nutrient-poor environment; however, the mechanisms by which PDAC cells undergo metabolic reprogramming to adapt to metabolic stress are still poorly understood. Here, we show that microRNA-135 is signifi...

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Publicado no:Nat Commun
Main Authors: Yang, Ying, Ishak Gabra, Mari B., Hanse, Eric A., Lowman, Xazmin H., Tran, Thai Q., Li, Haiqing, Milman, Neta, Liu, Juan, Reid, Michael A., Locasale, Jason W., Gil, Ziv, Kong, Mei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379428/
https://ncbi.nlm.nih.gov/pubmed/30778058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08759-0
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