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Membrane charge and lipid packing determine polymyxin-induced membrane damage

With the advent of polymyxin B (PmB) resistance in bacteria, the mechanisms for mcr-1 resistance are of crucial importance in the design of novel therapeutics. The mcr-1 phenotype is known to decrease membrane charge and increase membrane packing by modification of the bacterial outer membrane. We u...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Commun Biol
Main Authors: Khondker, Adree, Dhaliwal, Alexander K., Saem, Sokunthearath, Mahmood, Ahmad, Fradin, Cécile, Moran-Mirabal, Jose, Rheinstädter, Maikel C.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379423/
https://ncbi.nlm.nih.gov/pubmed/30793045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0297-6
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