Membrane Cholesterol Reduces Polymyxin B Nephrotoxicity in Renal Membrane Analogs

Polymyxin B (PmB) is a “last-line” antibiotic scarcely used due to its nephrotoxicity. However, the molecular basis for antibiotic nephrotoxicity is not clearly understood. We prepared kidney membrane analogs of detergent-susceptible membranes, depleted of cholesterol, and cholesterol enriched, resi...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Khondker, Adree, Alsop, Richard J., Dhaliwal, Alexander, Saem, Sokunthearath, Moran-Mirabal, Jose M., Rheinstädter, Maikel C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2017
Assuntos:
Membranes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685785/
https://ncbi.nlm.nih.gov/pubmed/29117525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.09.013
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