Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation

The E3 ligase membrane-associated ring-CH-type finger 6 (MARCH6) is a polytopic enzyme bound to the membranes of the endoplasmic reticulum. It controls levels of several known protein substrates, including a key enzyme in cholesterol synthesis, squalene monooxygenase. However, beyond its own autodeg...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Sharpe, Laura J., Howe, Vicky, Scott, Nicola A., Luu, Winnie, Phan, Lisa, Berk, Jason M., Hochstrasser, Mark, Brown, Andrew J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Lipids
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6378986/
https://ncbi.nlm.nih.gov/pubmed/30545937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005069
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