Cellular Cholesterol Regulates Ubiquitination and Degradation of the Cholesterol Export Proteins ABCA1 and ABCG1

The objective of this study was to examine the influence of cholesterol in post-translational control of ABCA1 and ABCG1 protein expression. Using CHO cell lines stably expressing human ABCA1 or ABCG1, we observed that the abundance of these proteins is increased by cell cholesterol loading. The res...

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Detalhes bibliográficos
Main Authors: Hsieh, Victar, Kim, Mi-Jurng, Gelissen, Ingrid C., Brown, Andrew J., Sandoval, Cecilia, Hallab, Jeannette C., Kockx, Maaike, Traini, Mathew, Jessup, Wendy, Kritharides, Leonard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953266/
https://ncbi.nlm.nih.gov/pubmed/24500716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.515890
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