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Copy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions
Mitochondrial DNA (mtDNA) deletions are associated with mitochondrial disease, and also accumulate during normal human ageing. The mechanisms underlying mtDNA deletions remain unknown although several models have been proposed. Here we use deep sequencing to characterize abundant mtDNA deletions in...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6377680/ https://ncbi.nlm.nih.gov/pubmed/30770810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08673-5 |
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