The ORMDL3 Asthma Gene Regulates ICAM1 and Has Multiple Effects on Cellular Inflammation

Rationale: Polymorphisms on chromosome 17q21 confer the major genetic susceptibility to childhood-onset asthma. Risk alleles positively correlate with ORMDL3 (orosomucoid-like 3) expression. The locus influences disease severity and the frequency of human rhinovirus (HRV)–initiated exacerbations. OR...

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Bibliografiska uppgifter
I publikationen:Am J Respir Crit Care Med
Huvudupphovsmän: Zhang, Youming, Willis-Owen, Saffron A. G., Spiegel, Sarah, Lloyd, Clare M., Moffatt, Miriam F., Cookson, William O. C. M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Thoracic Society 2019
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Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6376621/
https://ncbi.nlm.nih.gov/pubmed/30339462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201803-0438OC
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