Antibody-mediated biorecognition of myelin oligodendrocyte glycoprotein: computational evidence of demyelination-related epitopes

Antigen-antibody interaction is crucial in autoimmune disease pathogenesis, as multiple sclerosis and neuromyelitis optica. Given that, autoantibodies are essential biomolecules, of which the myelin oligodendrocyte glycoprotein (MOG) can figure as a target. Here we combined Molecular Dynamics (MD),...

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Publicado no:Sci Rep
Main Authors: Ierich, Jéssica Cristiane Magalhães, Brum, Doralina Guimarães, Moraes, Ariana de Souza, Higa, Akemi Martins, Garcia, Pâmela Soto, Miyazaki, Celina Massumi, Ferreira, Marystela, Peroni, Luís Antonio, Oliveira, Guedmiller Souza de, Franca, Eduardo de Faria, Freitas, Luiz Carlos Gomide, Leite, Fabio Lima
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6376134/
https://ncbi.nlm.nih.gov/pubmed/30765742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36578-8
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