SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination

BACKGROUND: S-phase kinase-associated protein 2 (SKP2) is an oncogene and cell cycle regulator that specifically recognizes phosphorylated cell cycle regulator proteins and mediates their ubiquitination. Programmed cell death protein 4 (PDCD4) is a tumor suppressor gene that plays a role in cell apo...

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Veröffentlicht in:J Exp Clin Cancer Res
Hauptverfasser: Li, Ce, Du, Lutao, Ren, Yidan, Liu, Xiaoyan, Jiao, Qinlian, Cui, Donghai, Wen, Mingxin, Wang, Chuanxin, Wei, Guangwei, Wang, Yunshan, Ji, Aiguo, Wang, Qin
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6375223/
https://ncbi.nlm.nih.gov/pubmed/30760284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1069-3
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