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Induction of MET Receptor Tyrosine Kinase Down-regulation through Antibody-mediated Receptor Clustering
The proto-oncoprotein MET is a receptor tyrosine kinase that plays a key role in cancer cell growth and invasion. We have used fluorescence-tagged antibodies to activate MET in live serum-starved glioblastoma cells and monitor the fate of antibody-bound MET receptor in single cell-based assays. We f...
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| Gepubliceerd in: | Sci Rep |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group UK
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6374517/ https://ncbi.nlm.nih.gov/pubmed/30760737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36963-3 |
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