Association of Low-Frequency Genetic Variants in Regulatory Regions with Non-Syndromic Orofacial Clefts

Genome-wide scans have shown that common risk alleles for orofacial clefts (OFC) tend to be located in non-coding regulatory elements and cumulatively explain only part of the heritability of OFCs. Low-frequency variants may account for some of the “missing” heritability. Therefore, we scanned low-f...

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Опубликовано в: :Am J Med Genet A
Главные авторы: Shaffer, John R., LeClair, Jessica, Carlson, Jenna C., Feingold, Eleanor, Buxó, Carmen J., Christensen, Kaare, Deleyiannis, Frederic W.B., Field, L. Leigh, Hecht, Jacqueline T., Moreno, Lina, Orioli, Ieda M., Padilla, Carmencita, Vieira, Alexandre R., Wehby, George L., Murray, Jeffrey C., Weinberg, Seth M., Marazita, Mary L., Leslie, Elizabeth J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6374160/
https://ncbi.nlm.nih.gov/pubmed/30582786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajmg.a.61002
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