RUNX1 mutations enhance self-renewal and block granulocytic differentiation in human in vitro models and primary AMLs

To unravel molecular mechanisms by which Runt-related transcription factor 1 (RUNX1) mutations contribute to leukemic transformation, we introduced the RUNX1-S291fs300X mutation in human CD34(+) stem/progenitor cells and in human induced pluripotent stem cells (iPSCs). In both models, RUNX1mut overe...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Blood Adv
मुख्य लेखकों: Gerritsen, Mylène, Yi, Guoqiang, Tijchon, Esther, Kuster, Jorren, Schuringa, Jan Jacob, Martens, Joost H. A., Vellenga, Edo
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society of Hematology 2019
विषय:
Hematopoiesis and Stem Cells
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6373749/
https://ncbi.nlm.nih.gov/pubmed/30709863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018024422
टैग : टैग जोड़ें
कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!

समान संसाधन