A fragment activity assay reveals the key residues of TBC1D15 GTPase-activating protein (GAP) in Chiloscyllium plagiosum

BACKGROUND: GTPase-activating proteins (GAPs) with a TBC (Tre-2/Bub2/Cdc16) domain architecture serve as negative regulators of Rab GTPases. The related crystal structure has been studied and reported by other members of our research group in 2017 (Chen et al. in Protein Sci 26(4):834–846, 2017). Th...

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Опубликовано в: :BMC Mol Biol
Главные авторы: Jin, Yangyang, Lin, Guodong, Chen, Yanna, Ge, Yinghua, Liang, Ruofeng, Wu, Jia, Chen, Jianqing, Wang, Dan, Shi, Hengbo, Fei, Hui, Lv, Zhengbing
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2019
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6373008/
https://ncbi.nlm.nih.gov/pubmed/30755162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12867-019-0122-2
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