X-Chromosome Dosage Modulates Multiple Molecular and Cellular Properties of Mouse Pluripotent Stem Cells Independently of Global DNA Methylation Levels

Reprogramming female mouse somatic cells into induced pluripotent stem cells (iPSCs) leads to X-chromosome reactivation. The extent to which increased X-chromosome dosage (X-dosage) in female iPSCs compared with male iPSCs leads to differences in the properties of iPSCs is still unclear. We show tha...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Song, Juan, Janiszewski, Adrian, De Geest, Natalie, Vanheer, Lotte, Talon, Irene, El Bakkali, Mouna, Oh, Taeho, Pasque, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6372905/
https://ncbi.nlm.nih.gov/pubmed/30639215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2018.12.004
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