Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes

Metabolic syndrome is characterized by disturbances in glucose homeostasis and the development of low-grade systemic inflammation, which increase the risk to develop type 2 diabetes mellitus (T2DM). Type-2 innate lymphoid cells (ILC2s) are a recently discovered immune population secreting Th2 cytoki...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Galle-Treger, Lauriane, Sankaranarayanan, Ishwarya, Hurrell, Benjamin P., Howard, Emily, Lo, Richard, Maazi, Hadi, Lewis, Gavin, Banie, Homayon, Epstein, Alan L., Hu, Peisheng, Rehan, Virender K., Gilliland, Frank D., Allayee, Hooman, Soroosh, Pejman, Sharpe, Arlene H., Akbari, Omid
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6372786/
https://ncbi.nlm.nih.gov/pubmed/30755607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08449-x
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