Adaptive F-actin polymerization and localized ATP production drive basement membrane invasion in the absence of MMPs

Matrix metalloproteinases (MMPs) are associated with decreased patient prognosis, but have failed as anti-invasive drug targets despite promoting cancer cell invasion. Through time-lapse imaging, optical highlighting, and combined genetic removal of the five MMPs expressed during anchor cell (AC) in...

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Bibliografske podrobnosti
izdano v:Dev Cell
Main Authors: Kelley, Laura C., Chi, Qiuyi, Cáceres, Rodrigo, Hastie, Eric, Schindler, Adam J., Jiang, Yue, Matus, David Q., Plastino, Julie, Sherwood, David R.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6372315/
https://ncbi.nlm.nih.gov/pubmed/30686527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.12.018
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