HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

Many viral pathogens target innate sensing cascades and/or cellular transcription factors to suppress antiviral immune responses. Here, we show that the accessory viral protein U (Vpu) of HIV-1 exerts broad immunosuppressive effects by inhibiting activation of the transcription factor NF-κB. Global...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Langer, Simon, Hammer, Christian, Hopfensperger, Kristina, Klein, Lukas, Hotter, Dominik, De Jesus, Paul D, Herbert, Kristina M, Pache, Lars, Smith, Nikaïa, van der Merwe, Johannes A, Chanda, Sumit K, Fellay, Jacques, Kirchhoff, Frank, Sauter, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Immunology and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6372280/
https://ncbi.nlm.nih.gov/pubmed/30717826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.41930
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