Local Tension on Talin in Focal Adhesions Correlates with F-Actin Alignment at the Nanometer Scale

Cellular force transmission and mechanotransduction are critical in embryogenesis, normal physiology, and many diseases. Talin plays a key role in these processes by linking integrins to force-generating actomyosin. Using the previously characterized FRET-based talin tension sensor, we observed vari...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Kumar, Abhishek, Anderson, Karen L., Swift, Mark F., Hanein, Dorit, Volkmann, Niels, Schwartz, Martin A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2018
Assuntos:
Molecular Machhines, Motors, and Nanoscale Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6372196/
https://ncbi.nlm.nih.gov/pubmed/30274833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.08.045
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