Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment

ROCK-Myosin II drives fast rounded-amoeboid migration in cancer cells during metastatic dissemination. Analysis of human melanoma biopsies revealed that amoeboid melanoma cells with high Myosin II activity are predominant in the invasive fronts of primary tumors in proximity to CD206(+)CD163(+) tumo...

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Publicat a:Cell
Autors principals: Georgouli, Mirella, Herraiz, Cecilia, Crosas-Molist, Eva, Fanshawe, Bruce, Maiques, Oscar, Perdrix, Anna, Pandya, Pahini, Rodriguez-Hernandez, Irene, Ilieva, Kristina M., Cantelli, Gaia, Karagiannis, Panagiotis, Mele, Silvia, Lam, Hoyin, Josephs, Debra H., Matias-Guiu, Xavier, Marti, Rosa M., Nestle, Frank O., Orgaz, Jose L., Malanchi, Ilaria, Fruhwirth, Gilbert O., Karagiannis, Sophia N., Sanz-Moreno, Victoria
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370915/
https://ncbi.nlm.nih.gov/pubmed/30712866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.12.038
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