Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment

ROCK-Myosin II drives fast rounded-amoeboid migration in cancer cells during metastatic dissemination. Analysis of human melanoma biopsies revealed that amoeboid melanoma cells with high Myosin II activity are predominant in the invasive fronts of primary tumors in proximity to CD206(+)CD163(+) tumo...

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Publicado no:Cell
Main Authors: Georgouli, Mirella, Herraiz, Cecilia, Crosas-Molist, Eva, Fanshawe, Bruce, Maiques, Oscar, Perdrix, Anna, Pandya, Pahini, Rodriguez-Hernandez, Irene, Ilieva, Kristina M., Cantelli, Gaia, Karagiannis, Panagiotis, Mele, Silvia, Lam, Hoyin, Josephs, Debra H., Matias-Guiu, Xavier, Marti, Rosa M., Nestle, Frank O., Orgaz, Jose L., Malanchi, Ilaria, Fruhwirth, Gilbert O., Karagiannis, Sophia N., Sanz-Moreno, Victoria
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370915/
https://ncbi.nlm.nih.gov/pubmed/30712866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.12.038
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