Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies

Platinum-based chemotherapies can result in ovarian insufficiency by reducing the ovarian reserve, a reduction believed to result from apoptosis of immature oocytes via activation/phosphorylation of TAp63α by multiple kinases including CHEK2, CK1, and ABL1. Here we demonstrate that cisplatin (CDDP)...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Kim, So-Youn, Nair, Devi M., Romero, Megan, Serna, Vanida A., Koleske, Anthony J., Woodruff, Teresa K., Kurita, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370889/
https://ncbi.nlm.nih.gov/pubmed/29988075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0151-2
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