Cell Autonomous Phosphoinositide 3-Kinase Activation in Oocytes Disrupts Normal Ovarian Function Through Promoting Survival and Overgrowth of Ovarian Follicles

In this study, we explored the effects of oocytic phosphoinositide 3-kinase (PI3K) activation on folliculogensis by generating transgenic mice, in which the oocyte-specific Cre-recombinase induces the expression of constitutively active mutant PI3K during the formation of primordial follicles. The o...

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Detalhes bibliográficos
Publicado no:Endocrinology
Main Authors: Kim, So-Youn, Ebbert, Katherine, Cordeiro, Marilia H., Romero, Megan, Zhu, Jie, Serna, Vanida Ann, Whelan, Kelly A., Woodruff, Teresa K., Kurita, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2015
Assuntos:
Reproduction-Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4399322/
https://ncbi.nlm.nih.gov/pubmed/25594701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1926
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