Constitutive IP(3) signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP(3) receptor disruptor BIRD-2

Anti-apoptotic Bcl-2 proteins are upregulated in different cancers, including diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL), enabling survival by inhibiting pro-apoptotic Bcl-2-family members and inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R)-mediated Ca(2+)-si...

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Pubblicato in:Cell Death Differ
Autori principali: Bittremieux, Mart, La Rovere, Rita M., Akl, Haidar, Martines, Claudio, Welkenhuyzen, Kirsten, Dubron, Kathia, Baes, Myriam, Janssens, Ann, Vandenberghe, Peter, Laurenti, Luca, Rietdorf, Katja, Morciano, Giampaolo, Pinton, Paolo, Mikoshiba, Katsuhiko, Bootman, Martin D., Efremov, Dimitar G., De Smedt, Humbert, Parys, Jan B., Bultynck, Geert
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370760/
https://ncbi.nlm.nih.gov/pubmed/29899382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0142-3
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