Constitutive IP(3) signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP(3) receptor disruptor BIRD-2

Anti-apoptotic Bcl-2 proteins are upregulated in different cancers, including diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL), enabling survival by inhibiting pro-apoptotic Bcl-2-family members and inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R)-mediated Ca(2+)-si...

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Publicado no:Cell Death Differ
Main Authors: Bittremieux, Mart, La Rovere, Rita M., Akl, Haidar, Martines, Claudio, Welkenhuyzen, Kirsten, Dubron, Kathia, Baes, Myriam, Janssens, Ann, Vandenberghe, Peter, Laurenti, Luca, Rietdorf, Katja, Morciano, Giampaolo, Pinton, Paolo, Mikoshiba, Katsuhiko, Bootman, Martin D., Efremov, Dimitar G., De Smedt, Humbert, Parys, Jan B., Bultynck, Geert
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370760/
https://ncbi.nlm.nih.gov/pubmed/29899382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0142-3
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