Reciprocal sensitivity of diffuse large B-cell lymphoma cells to Bcl-2 inhibitors BIRD-2 versus venetoclax

Bcl-2 is often upregulated in cancers to neutralize the BH3-only protein Bim at the mitochondria. BH3 mimetics (e.g. ABT-199 (venetoclax)) kill cancer cells by targeting Bcl-2’s hydrophobic cleft and disrupting Bcl-2/Bim complexes. Some cancers with elevated Bcl-2 display poor responses towards BH3...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Vervloessem, Tamara, Akl, Haidar, Tousseyn, Thomas, De Smedt, Humbert, Parys, Jan B., Bultynck, Geert
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762350/
https://ncbi.nlm.nih.gov/pubmed/29340082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22898
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