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Oncogenic β-catenin mutations evade pH-regulated degradation
β-catenin has roles in cell-cell adhesion and Wnt signaling. We recently showed that β-catenin protein abundance is decreased at higher intracellular pH (pHi), mediated by pH-sensitive interaction with the beta-transducin repeat containing E3 ubiquitin protein ligase (β-TrCP). Increased pHi facilita...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Mol Cell Oncol |
|---|---|
| Prif Awduron: | , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Taylor & Francis
2019
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6370367/ https://ncbi.nlm.nih.gov/pubmed/30788422 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2018.1554470 |
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