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A Histidine Cluster in the Cytoplasmic Domain of the Na-H Exchanger NHE1 Confers pH-sensitive Phospholipid Binding and Regulates Transporter Activity
The Na-H exchanger NHE1 contributes to intracellular pH (pH(i)) homeostasis in normal cells and the constitutively increased pH(i) in cancer. NHE1 activity is allosterically regulated by intracellular protons, with greater activity at lower pH(i). However, the molecular mechanism for pH-dependent NH...
Tallennettuna:
| Julkaisussa: | J Biol Chem |
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| Päätekijät: | , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Biochemistry and Molecular Biology
2016
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5104935/ https://ncbi.nlm.nih.gov/pubmed/27650500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.736215 |
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