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Interleukin-17 signaling triggers degradation of the constitutive NF-κB inhibitor ABIN-1
IL-17 activates NF-κB and inducing expression of proinflammatory genes. IL-17 drives disease in autoimmune conditions, and anti-IL-17 antibodies have shown impressive success in the clinic. Although produced by lymphocytes, IL-17 predominantly signals in fibroblasts and epithelial cells. IL-17-drive...
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| 出版年: | Immunohorizons |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2017
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6370333/ https://ncbi.nlm.nih.gov/pubmed/30761389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/immunohorizons.1700035 |
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