Interleukin-17 signaling triggers degradation of the constitutive NF-κB inhibitor ABIN-1

IL-17 activates NF-κB and inducing expression of proinflammatory genes. IL-17 drives disease in autoimmune conditions, and anti-IL-17 antibodies have shown impressive success in the clinic. Although produced by lymphocytes, IL-17 predominantly signals in fibroblasts and epithelial cells. IL-17-drive...

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Detalhes bibliográficos
Publicado no:Immunohorizons
Main Authors: Cruz, J. Agustin, Childs, Erin E., Amatya, Nilesh, Garg, Abhishek V., Beyaert, Rudi, Kane, Lawrence P., Aneskievich, Brian J., Ma, Averil, Gaffen, Sarah L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370333/
https://ncbi.nlm.nih.gov/pubmed/30761389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/immunohorizons.1700035
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