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Angiogenic Host Defense Peptide AG-30/5C and Bradykinin B(2) receptor antagonist Icatibant are G protein-biased agonists for MRGPRX2 in mast cells
AG-30/5C is an angiogenic host defense peptide (HDP) that activates human mast cells (MC) via an unknown mechanism. Using shRNA-silenced human MC line (LAD2) and stably transfected RBL-2H3 cells, we demonstrate that AG-30/5C induces MC degranulation via Mas-related G protein coupled receptor (GPCR)...
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| Publicat a: | J Immunol |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6369923/ https://ncbi.nlm.nih.gov/pubmed/30651343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1801227 |
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