Icatibant Acts as a Balanced Ligand of MRGPRX2 in Human Skin Mast Cells

MRGPRX2 (Mas-related G protein-coupled receptor member X2) is implicated in mast cell (MC)-driven disorders due to its ability to bind diverse ligands, which may be G-protein-biased or balanced, with the latter activating both G-proteins and the β-arrestin pathway. Icatibant, a peptide drug, produce...

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Hlavní autoři:	Zhuoran Li, Jean Schneikert, Gürkan Bal, Torsten Zuberbier, Magda Babina
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2025-08-01
Edice:	Biomolecules
Témata:	mast cells MRGPRX2 degranulation icatibant drug allergy desensitization
On-line přístup:	https://www.mdpi.com/2218-273X/15/9/1224
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