Molecular mechanism for NLRP6 inflammasome assembly and activation

Inflammasomes are large protein complexes that trigger host defense in cells by activating inflammatory caspases for cytokine maturation and pyroptosis. NLRP6 is a sensor protein in the nucleotide-binding domain (NBD) and leucine-rich repeat (LRR)-containing (NLR) inflammasome family that has been s...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Shen, Chen, Lu, Alvin, Xie, Wen Jun, Ruan, Jianbin, Negro, Roberto, Egelman, Edward H., Fu, Tian-Min, Wu, Hao
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2019
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6369754/
https://ncbi.nlm.nih.gov/pubmed/30674671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1817221116
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