Amitriptyline inhibits the MAPK/ERK and CREB pathways and proinflammatory cytokines through A3AR activation in rat neuropathic pain models

BACKGROUND: The pain-relief properties of tricyclic antidepressants can be attributed to several actions. Recent observations suggest that adenosine is involved in the antinociceptive effect of amitriptyline. The A3 adenosine receptor (A3AR) is the only adenosine subtype overexpressed in inflammator...

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Detaylı Bibliyografya
Yayımlandı:Korean J Anesthesiol
Asıl Yazarlar: Kim, Yumi, Kwon, So Young, Jung, Hong Soo, Park, Yoo Jung, Kim, Yong Shin, In, Jang Hyeok, Choi, Jin Woo, Kim, Jin A, Joo, Jin Deok
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Korean Society of Anesthesiologists 2019
Konular:
Experimental Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6369348/
https://ncbi.nlm.nih.gov/pubmed/29969887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4097/kja.d.18.00022
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