Amitriptyline inhibits the MAPK/ERK and CREB pathways and proinflammatory cytokines through A3AR activation in rat neuropathic pain models

BACKGROUND: The pain-relief properties of tricyclic antidepressants can be attributed to several actions. Recent observations suggest that adenosine is involved in the antinociceptive effect of amitriptyline. The A3 adenosine receptor (A3AR) is the only adenosine subtype overexpressed in inflammator...

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Detalhes bibliográficos
Publicado no:Korean J Anesthesiol
Main Authors: Kim, Yumi, Kwon, So Young, Jung, Hong Soo, Park, Yoo Jung, Kim, Yong Shin, In, Jang Hyeok, Choi, Jin Woo, Kim, Jin A, Joo, Jin Deok
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society of Anesthesiologists 2019
Assuntos:
Experimental Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6369348/
https://ncbi.nlm.nih.gov/pubmed/29969887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4097/kja.d.18.00022
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