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Hepatocellular Cancer-Derived Alpha Fetoprotein Uptake Reduces CD1 Molecules on Monocyte-derived Dendritic Cells

Alpha fetoprotein (AFP) is produced by over 50% of hepatocellular carcinomas (HCC). Uptake of tumor-derived AFP (tAFP) can impair activity of human dendritic cells (DC). The expression pattern of the lipid antigen presenting genes from the CD1 family is reduced in AFP-treated monocyte-derived DC. Su...

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Udgivet i:Cell Immunol
Main Authors: Li, Chunlei, Song, Baobao, Santos, Patricia M., Butterfield, Lisa H.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6368446/
https://ncbi.nlm.nih.gov/pubmed/30392891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2018.10.011
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