Robust CRISPR/Cas9-Mediated Tissue-Specific Mutagenesis Reveals Gene Redundancy and Perdurance in Drosophila

Tissue-specific loss-of-function (LOF) analysis is essential for characterizing gene function. Here, we present a simple, yet highly efficient, clustered regularly interspaced short palindromic repeats (CRISPR)-mediated tissue-restricted mutagenesis (CRISPR-TRiM) method for ablating gene function in...

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Vydáno v:Genetics
Hlavní autoři: Poe, Amy R., Wang, Bei, Sapar, Maria L., Ji, Hui, Li, Kailyn, Onabajo, Tireniolu, Fazliyeva, Rushaniya, Gibbs, Mary, Qiu, Yue, Hu, Yuzhao, Han, Chun
Médium: Artigo
Jazyk:Inglês
Vydáno: Genetics Society of America 2019
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Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6366929/
https://ncbi.nlm.nih.gov/pubmed/30504366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.118.301736
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