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NEDD4 over-expression regulates the afatinib resistant phenotype of NSCLC cells
We focused on defining the role of the E3 ligase NEDD4 in NSCLC cell afatinib resistance. Afatinib resistant H1975 clones over-expressed NEDD4 and c-MET compared to control clones and expressed less ERBB1, ERBB3, ERBB4 and PTEN than control clones. Knock down of NEDD4 enhanced the expression of PTEN...
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| Udgivet i: | Oncol Signal |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6366836/ https://ncbi.nlm.nih.gov/pubmed/30740589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.onsig.2017.07.001 |
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