The afatinib resistance of in vivo generated H1975 lung cancer cell clones is mediated by SRC/ERBB3/c-KIT/c-MET compensatory survival signaling

We generated afatinib resistant clones of H1975 lung cancer cells by transient exposure of established tumors to the drug and collected the re-grown tumors. Afatinib resistant H1975 clones did not exhibit any additional mutations in proto-oncogenes when compared to control clones. Afatinib resistant...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Booth, Laurence, Roberts, Jane L., Tavallai, Mehrad, Webb, Timothy, Leon, Daniel, Chen, Jesse, McGuire, William P., Poklepovic, Andrew, Dent, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991406/
https://ncbi.nlm.nih.gov/pubmed/26934000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7746
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