[Pemetrexed + Sorafenib] lethality is increased by inhibition of ERBB1/2/3-PI3K-NFκB compensatory survival signaling

In the completed phase I trial NCT01450384 combining the anti-folate pemetrexed and the multi-kinase inhibitor sorafenib it was observed that 20 of 33 patients had prolonged stable disease or tumor regression, with one complete response and multiple partial responses. The pre-clinical studies in thi...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Booth, Laurence, Roberts, Jane L., Tavallai, Mehrad, Chuckalovcak, John, Stringer, Daniel K., Koromilas, Antonis E., Boone, David L., McGuire, William P., Poklepovic, Andrew, Dent, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029651/
https://ncbi.nlm.nih.gov/pubmed/27015562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8281
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