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Interim Futility Monitoring Assessing Immune Therapies With a Potentially Delayed Treatment Effect

PURPOSE: Introduction of new immune therapies that may have a delayed beneficial effect necessitates re-evaluation of traditional clinical trial designs in oncology. A key design feature of randomized trials is interim futility monitoring, which allows stopping early if the accruing data convincingl...

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Опубликовано в: :J Clin Oncol
Главные авторы: Korn, Edward L., Freidlin, Boris
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Clinical Oncology 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6366306/
https://ncbi.nlm.nih.gov/pubmed/29949395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2018.77.7144
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