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Comparison of futility monitoring guidelines using completed phase III oncology trials

BACKGROUND: Futility (inefficacy) interim monitoring is an important component in the conduct of phase III clinical trials, especially in life threatening diseases. Desirable futility monitoring guidelines allow timely stopping if the new therapy is harmful or if it is unlikely to demonstrate to be...

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Publicado en:Clin Trials
Main Authors: Zhang, Qiang, Freidlin, Boris, Korn, Edward L, Halabi, Susan, Mandrekar, Sumithra, Dignam, James J
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5300958/
https://ncbi.nlm.nih.gov/pubmed/27590208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774516666502
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