Co-inhibition of PGF and VEGF blocks their expression in mononuclear phagocytes and limits neovascularization and leakage in the murine retina

BACKGROUND: Age-related macular degeneration (AMD) is a leading cause of visual impairment in the elderly. The neovascular (wet) form of AMD can be treated with intravitreal injections of different anti-vascular endothelial growth factor (VEGF) agents. Placental growth factor (PGF) is another member...

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Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Balser, Carsten, Wolf, Anne, Herb, Marc, Langmann, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6366121/
https://ncbi.nlm.nih.gov/pubmed/30732627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-019-1419-2
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