Elevated apoptosis impairs epithelial cell turnover and shortens villi in TNF-driven intestinal inflammation

The intestinal epithelial monolayer, at the boundary between microbes and the host immune system, plays an important role in the development of inflammatory bowel disease (IBD), particularly as a target and producer of pro-inflammatory TNF. Chronic overexpression of TNF leads to IBD-like pathology o...

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Publicat a:Cell Death Dis
Autors principals: Parker, Aimée, Vaux, Laura, Patterson, Angela M., Modasia, Amisha, Muraro, Daniele, Fletcher, Alexander G., Byrne, Helen M., Maini, Philip K., Watson, Alastair J. M., Pin, Carmen
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365534/
https://ncbi.nlm.nih.gov/pubmed/30728350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1275-5
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