Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

In this trans-ethnic multi-omic study we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenome, and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in GWASs of systolic, diastolic and puls...

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Publicat a:Nat Genet
Autors principals: Giri, Ayush, Hellwege, Jacklyn N., Keaton, Jacob M., Park, Jihwan, Qiu, Chengxiang, Warren, Helen R., Torstenson, Eric S., Kovesdy, Csaba P., Sun, Yan V., Wilson, Otis D., Robinson-Cohen, Cassianne, Roumie, Christianne L., Chung, Cecilia P., Birdwell, Kelly A., Damrauer, Scott M., DuVall, Scott L., Klarin, Derek, Cho, Kelly, Wang, Yu, Evangelou, Evangelos, Cabrera, Claudia P., Wain, Louise V., Shrestha, Rojesh, Mautz, Brian S., Akwo, Elvis A., Sargurupremraj, Muralidharan, Debette, Stéphanie, Boehnke, Michael, Scott, Laura J., Luan, Jian’an, Jing-Hua, Zhao, Willems, Sara M., Thériault, Sébastien, Shah, Nabi, Oldmeadow, Christopher, Almgren, Peter, Li-Gao, Ruifang, Verweij, Niek, Boutin, Thibaud S., Mangino, Massimo, Ntalla, Ioanna, Feofanova, Elena, Surendran, Praveen, Cook, James P., Karthikeyan, Savita, Lahrouchi, Najim, Liu, Chunyu, Sepúlveda, Nuno, Richardson, Tom G., Kraja, Aldi, Amouyel, Philippe, Farrall, Martin, Poulter, Neil R., Laakso, Markku, Zeggini, Eleftheria, Sever, Peter, Scott, Robert A., Langenberg, Claudia, Wareham, Nicholas J., Conen, David, Alexander Palmer, Colin Neil, Attia, John, Chasman, Daniel I., Ridker, Paul M., Melander, Olle, Mook-Kanamori, Dennis Owen, van der Harst, Pim, Cucca, Francesco, Schlessinger, David, Hayward, Caroline, Spector, Tim D., Marjo-Riitta, Jarvelin, Hennig, Branwen J., Timpson, Nicholas J., Wei-Qi, Wei, Smith, Joshua C., Xu, Yaomin, Matheny, Michael E., Siew, Edward E., Lindgren, Cecilia, Karl-Heinz, Herzig, Dedoussis, George, Denny, Joshua C., Psaty, Bruce M., Howson, Joanna M. M., Munroe, Patricia B., Newton-Cheh, Christopher, Caulfield, Mark J., Elliott, Paul, Gaziano, J. Michael, Concato, John, Wilson, Peter W.F., Tsao, Philip S., Velez Edwards, Digna R., Susztak, Katalin, O’Donnell, Christopher J., Hung, Adriana M., Edwards, Todd L.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365102/
https://ncbi.nlm.nih.gov/pubmed/30578418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0303-9
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