GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump

The sodium potassium pump (Na/K-ATPase) ensures the electrochemical gradient of a cell through an energy-dependent process that consumes approximately one third of regenerated ATP. We report that the G protein-coupled receptor GPR35 interacted with the α chain of Na/K-ATPase and promotes its ion tra...

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Udgivet i:Sci Signal
Main Authors: Schneditz, Georg, Elias, Joshua E., Pagano, Ester, Zaeem Cader, M., Saveljeva, Svetlana, Long, Kathleen, Mukhopadhyay, Subhankar, Arasteh, Maryam, Lawley, Trevor D., Dougan, Gordon, Bassett, Andrew, Karlsen, Tom H., Kaser, Arthur, Kaneider, Nicole C.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6364804/
https://ncbi.nlm.nih.gov/pubmed/30600262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aau9048
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