A positive feedback mechanism ensures proper assembly of the functional inner centromere during mitosis in human cells

The inner centromere region of a mitotic chromosome critically regulates sister chromatid cohesion and kinetochore–microtubule attachments. However, the molecular mechanism underlying inner centromere assembly remains elusive. Here, using CRISPR/Cas9-based gene editing in HeLa cells, we disrupted th...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Liang, Cai, Zhang, Zhenlei, Chen, Qinfu, Yan, Haiyan, Zhang, Miao, Xiang, Xingfeng, Yi, Qi, Pan, Xuan, Cheng, Hankun, Wang, Fangwei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6364785/
https://ncbi.nlm.nih.gov/pubmed/30498087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006046
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